Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

parC mutations in fluoroquinolone-resistant Borrelia burgdorferi.

Antimicrobial agents and chemotherapy - 1 Oct 2005

Galbraith Kendal M, Ng Amanda C, Eggers Betsy J, Kuchel Craig R, Eggers Christian H, Samuels D Scott

Abstract excerpt

We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Infective Agents
Share to Borrelia burgdorferi
Share to Drug Resistance, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluoroquinolones

Share to Genes, Bacterial

Share to Inhibitory Concentration 50

Share to Microbial Sensitivity Tests

Share to Nucleic Acid Amplification Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 16189120
DOI: 10.1128/AAC.49.10.4354-4357.2005
PMCID: PMC1251557

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

parC mutations in fluoroquinolone-resistant Borrelia burgdorferi.PMID 16189120Read ↗

Quinolone-resistance mutations in the topoisomerase IV parC gene of Acinetobacter baumanniiSemantic proximity Read ↗

Quinolone-resistant mutants of escherichia coli DNA topoisomerase IV parC gene.Semantic proximity Read ↗

Alterations in the GyrA Subunit of DNA Gyrase and the ParC Subunit of DNA Topoisomerase IV Associated with Quinolone Resistance in Enterococcus faecalisSemantic proximity Read ↗

Rapid assay for detecting gyrA and parC mutations associated with fluoroquinolone resistance in Enterobacteriaceae.Semantic proximity Read ↗

Fluoroquinolone resistance linked to both gyrA and parC mutations in the quinolone resistance-determining region of Shigella dysenteriae type 1.Semantic proximity Read ↗

A mutation in QRDR in the ParC subunit of topoisomerase IV was responsible for fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae.Semantic proximity Read ↗

Mutations in the gyrA and parC genes in fluoroquinolone-resistant clinical isolates of Pseudomonas aeruginosa.Semantic proximity Read ↗

Detection of mutations in parC in quinolone-resistant clinical isolates of Escherichia coli.Semantic proximity Read ↗

Fluoroquinolone Resistance Linked to GyrA, GyrB, and ParC Mutations in<i>Salmonella</i><i>enterica</i>Typhimurium Isolates in HumansSemantic proximity Read ↗

Mutations in the gyrA, parC, and parE genes associated with fluoroquinolone resistance in clinical isolates of Mycoplasma hominis.Semantic proximity Read ↗

Alterations in DNA gyrase and topoisomerase IV in resistant mutants of Clostridium perfringens found after in vitro treatment with fluoroquinolones.Semantic proximity Read ↗

Contribution of topoisomerase IV and DNA gyrase mutations in Streptococcus pneumoniae to resistance to novel fluoroquinolones.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.