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Fluoroquinolone Resistance Linked to GyrA, GyrB, and ParC Mutations in<i>Salmonella</i><i>enterica</i>Typhimurium Isolates in Humans

1 Nov 2003

Abstract excerpt

We report two cases of infection with clonally unrelated, high-level ciprofloxacin-resistant, b-lactamase-producing strains of Salmonella enterica Typhimurium. Resistance was caused by four topoisomerase mutations, in GyrA, GyrB, and ParC and increased drug efflux. Ciprofloxacin treatment failed in one case. In the second case, reduced susceptibility to third-generation cephalosporins occurred after initial...

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PMID: 14718091
DOI: 10.3201/eid0911.030317

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