Article
Detection of mutations in parC in quinolone-resistant clinical isolates of Escherichia coli.
Antimicrobial agents and chemotherapy - 1 Feb 1996
Vila J, Ruiz J, Goñi P, De Anta M T
Abstract excerpt
The gene parC encodes the A subunit of topoisomerase IV of Escherichia coli. Mutations in the parC region analogous to those in the quinolone resistance-determining region of gyrA were investigated in 27 clinical isolates of E. coli for which ciprofloxacin MICs were 0.0007 to 128 micrograms/ml. O...
Topics
- Anti-Infective Agents
- Antigens, Neoplasm
- Base Sequence
- Ciprofloxacin
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- DNA-Binding Proteins
- Drug Resistance, Microbial
- Escherichia coli
- Isoenzymes
- Molecular Sequence Data
- Mutation
- Sequence Homology, Amino Acid