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Alterations in DNA gyrase and topoisomerase IV in resistant mutants of Clostridium perfringens found after in vitro treatment with fluoroquinolones.

Antimicrobial agents and chemotherapy - 1 Feb 2005

Rafii Fatemeh, Park Miseon, Novak John S

Abstract excerpt

To compare mutations in the DNA gyrase (gyrA and gyrB) and topoisomerase IV (parC and parE) genes of Clostridium perfringens, which are associated with in vitro exposure to fluoroquinolones, resistant mutants were selected from eight strains by serial passage in the presence of increasing concentrations of norfloxacin, ciprofloxacin, gatifloxacin, or trovafloxacin. The nucleotide sequences of the entire gyrA,...

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Identifiers

PMID: 15673722
DOI: 10.1128/AAC.49.2.488-492.2005
PMCID: PMC547304

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Source receipt: pubmed, retrieved 7 Sept 2026.

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