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Article

HLA-DQ8 is a predisposing molecule for detergent enzyme subtilisin BPN'-induced hypersensitivity.

Clinical immunology (Orlando, Fla.) - 1 Dec 2005

Xue Ailing, Chapoval Svetlana P, Finn Elizabeth S, Chowdhary Vaidehi R, Marietta Eric V, Gaffey Thomas A, Pursifull Alex C, David Chella S

Abstract excerpt

Several million individuals are exposed to agents in the workplace associated with atopy and asthma. Detergent enzymes have been implicated in occupationally induced hypersensitivity. However, the genetic susceptibility and T cell responses to detergent enzymes are undefined. We generated and used HLA-DQ6, -DQ8, -DR2, -DR3, and -DR4 transgenic mice to examine the immune and inflammatory components involved in the...

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Source

Identifiers

PMID: 16185928
DOI: 10.1016/j.clim.2005.08.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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