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Article

Cellular and humoral immunity in arthritis are profoundly influenced by the interaction between cigarette smoke effects and host HLA-DR and DQ genes.

Clinical immunology (Orlando, Fla.) - 1 Jan 2000

Vassallo Robert, Luckey David, Behrens Marshall, Madden Benjamin, Luthra Harvinder, David Chella, Taneja Veena

Abstract excerpt

Individuals carrying DRB1*0401 who smoke cigarettes are at an increased risk of developing severe seropositive RA. To determine how cigarette smoke (CS) interacts with host genetic factors in the induction of RA-associated autoimmunity, we used transgenic mice carrying the RA-susceptible HLA genes DR4 and DQ8, but lacking all endogenous murine class II molecules. Cigarette smoke exposure augmented...

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Identifiers

PMID: 24631425
DOI: 10.1016/j.clim.2014.02.002
PMCID: PMC4004713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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