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Article

High rate of virological failure in maintenance antiretroviral therapy with didanosine and tenofovir.

AIDS (London, England) - 14 Oct 2005

León Agathe, Mallolas Josep, Martinez Esteban, De Lazzari Elisa, Pumarola Tomás, Larrousse María, Milincovic Ana, Lonca Montserrat, Blanco Jose Luis, Laguno Montserrat, Biglia Alejandra, Gatell Josep María

Abstract excerpt

We evaluated the virological outcome of tenofovir plus didanosine-based regimens in 67 HIV-suppressed patients. After a median follow-up of 26 months (IQR 10.5-40.5), 12 (18%) discontinued the therapy because of virological failure. At virological failure 'de novo' selected mutations were identified in 11 of the 12 failing patients, including the K65R mutation in seven patients. These results argue against the...

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Identifiers

PMID: 16184042
DOI: 10.1097/01.aids.0000186821.30489.16

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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