Article
Efficacy of first-line ART regimens based on tenofovir in HIV-infected patients with pre-existing A62V mutation in reverse transcriptase.
Voprosy virusologii - 5 Jul 2024
Ozhmegova E N, Kuznetsova A I, Lebedev A V, Antonova A A, Kim K V, Munchak Y M, Tumanov A S, Kazennova E V
Abstract excerpt
INTRODUCTION: The amino acid substitution A62V in reverse transcriptase was identified as a mutation correlated with virologic failure in patients on first-line therapy including tenofovir (TDF) and tenofovir alafenamide (TAF). A62V is a typically polymorphic mutation in HIV-1 sub-subtype A6, which is the most widespread virus variant in Russia. MATERIALS AND METHODS: The European EuResist (EIDB) database was...
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