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Article

Sexually dimorphic serotonergic dysfunction in a mouse model of Huntington's disease and depression.

PloS one - 1 Jan 2011

Renoir Thibault, Zajac Michelle S, Du Xin, Pang Terence Y, Leang Leah, Chevarin Caroline, Lanfumey Laurence, Hannan Anthony J

Abstract excerpt

Depression is the most common psychiatric disorder in Huntington's disease (HD) patients. In the general population, women are more prone to develop depression and such susceptibility might be related to serotonergic dysregulation. There is yet to be a study of sexual dimorphism in the development and presentation of depression in HD patients. We investigated whether 8-week-old male and female R6/1 transgenic HD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21760962
DOI: 10.1371/journal.pone.0022133
PMCID: PMC3132782

Genes

FST
TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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