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Article

The molecular basis for the mode of action of bicyclomycin.

Current drug targets. Infectious disorders - 1 Sept 2005

Kohn Harold, Widger William

Abstract excerpt

Bicyclomycin (1) is a clinically useful antibiotic exhibiting activity against a broad spectrum of Gram-negative bacteria and against the Gram-positive bacterium, Micrococcus luteus. Bicyclomycin has been used to treat diarrhea in humans and bacterial diarrhea in calves and pigs and is marketed by Fujisawa (Osaka, Japan) under the trade name Bicozamycin. The structure of 1 is unique among antibiotics, and our...

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Source

Identifiers

PMID: 16181146
DOI: 10.2174/1568005054880136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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The molecular basis for the mode of action of bicyclomycin.PMID 16181146Read ↗

Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic bicyclomycin.Semantic proximity Read ↗

Transcription termination factor Rho is essential for Micrococcus luteus.Semantic proximity Read ↗

Transcription termination factor rho: the site of bicyclomycin inhibition in Escherichia coli.Semantic proximity Read ↗

The bicyclomycin sensitivities of 38 bicyclomycin-resistant mutants of transcription termination protein rho and the location of their mutations support a structural model of rho based on the F(1) ATPase.Semantic proximity Read ↗

Identification of the Biosynthetic Pathway for the Antibiotic BicyclomycinSemantic proximity Read ↗

Phenotypic characterization of a comprehensive set of bicyclomycin-resistant mutants.Semantic proximity Read ↗

Bicyclomycin generates ROS and blocks cell division in <i>Escherichia coli</i>Semantic proximity Read ↗

Inhibition of Rho Activity Increases Expression of SaeRS-Dependent Virulence Factor Genes in Staphylococcus aureus, Showing a Link between Transcription Termination, Antibiotic Action, and VirulenceSemantic proximity Read ↗

Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classesSemantic proximity Read ↗

Discovery and Biosynthesis of the Antibiotic Bicyclomycin in Distantly Related Bacterial ClassesSemantic proximity Read ↗

Study of bicyclomycin biosynthesis in Streptomyces cinnamoneus by genetic and biochemical approaches.Semantic proximity Read ↗

Mutations in the essential Escherichia coli gene, yqgF, and their effects on transcription.Semantic proximity Read ↗

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