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Article

Transcription termination factor rho: the site of bicyclomycin inhibition in Escherichia coli.

Biochemistry - 13 Apr 1993

Zwiefka A, Kohn H, Widger W R

Abstract excerpt

Bicyclomycin is a novel, commercially important antibiotic. Information concerning the site of bicyclomycin inhibition in Escherichia coli has been obtained by the production of bicyclomycin resistant mutants by UV irradiation. Selection by growth in the presence of bicyclomycin of a plasmid clone library generated from a highly resistant mutant in recipient antibiotic-sensitive host cells (E. coli strain W3350)...

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Identifiers

PMID: 8466900
DOI: 10.1021/bi00065a007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Transcription termination factor rho: the site of bicyclomycin inhibition in Escherichia coli.PMID 8466900Read ↗

The bicyclomycin sensitivities of 38 bicyclomycin-resistant mutants of transcription termination protein rho and the location of their mutations support a structural model of rho based on the F(1) ATPase.Semantic proximity Read ↗

The molecular basis for the mode of action of bicyclomycin.Semantic proximity Read ↗

Phenotypic characterization of a comprehensive set of bicyclomycin-resistant mutants.Semantic proximity Read ↗

Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic bicyclomycin.Semantic proximity Read ↗

Bicyclomycin sensitivity and resistance affect Rho factor-mediated transcription termination in the tna operon of Escherichia coli.Semantic proximity Read ↗

Transcription termination factor Rho is essential for Micrococcus luteus.Semantic proximity Read ↗

Bicyclomycin generates ROS and blocks cell division in <i>Escherichia coli</i>Semantic proximity Read ↗

Amino acid substitutions in the two largest subunits of Escherichia coli RNA polymerase that suppress a defective Rho termination factor affect different parts of the transcription complex.Semantic proximity Read ↗

Participation of Rho-dependent transcription termination in oxidative stress sensitivity caused by an rpoB mutation.Semantic proximity Read ↗

In vitro characterization of transcription termination factor Rho from Escherichia coli rho(nusD) mutants.Semantic proximity Read ↗

Mutations in the ATP-binding domain of Escherichia coli rho factor affect transcription termination in vivo.Semantic proximity Read ↗

Transcription termination defective mutants of Rho: role of different functions of Rho in releasing RNA from the elongation complex.Semantic proximity Read ↗

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