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Article

Disulfide bridge formation influences ligand recognition by the ATAD2 bromodomain.

Proteins - 1 Feb 2019

Gay Jamie C, Eckenroth Brian E, Evans Chiara M, Langini Cassiano, Carlson Samuel, Lloyd Jonathan T, Caflisch Amedeo, Glass Karen C

Abstract excerpt

The ATPase family, AAA domain-containing protein 2 (ATAD2) has a C-terminal bromodomain, which functions as a chromatin reader domain recognizing acetylated lysine on the histone tails within the nucleosome. ATAD2 is overexpressed in many cancers and its expression is correlated with poor patient outcomes, making it an attractive therapeutic target and potential biomarker. We solved the crystal structure of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30520161
DOI: 10.1002/prot.25636
PMCID: PMC6457126

Genes

ATAD2

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