Article
Genotype at the -174G/C polymorphism of the interleukin-6 gene is associated with common carotid artery intimal-medial thickness: family study and meta-analysis.
Stroke - 1 Oct 2005
Mayosi Bongani M, Avery Peter J, Baker Michelle, Gaukrodger Nicole, Imrie Helen, Green Fiona R, Farrall Martin, Watkins Hugh, Keavney Bernard
Abstract excerpt
BACKGROUND AND PURPOSE: Studies in unrelated individuals have produced conflicting findings concerning the putative association between the interleukin-6 (IL-6) -174G/C polymorphism and carotid intimal-medial thickness (IMT). We have used a family-based genetic association design to assess the heritability of carotid IMT and to investigate the hypothesized association of carotid IMT with the IL-6 to -174G/C...
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