Article
Carotid intima-media thickness is associated with allelic variants of stromelysin-1, interleukin-6, and hepatic lipase genes: the Northern Manhattan Prospective Cohort Study.
Stroke - 1 May 2002
Rundek Tanja, Elkind Mitchell S, Pittman John, Boden-Albala Bernadette, Martin Steve, Humphries Steve E, Juo Suh-Hang Hank, Sacco Ralph L
Abstract excerpt
BACKGROUND AND PURPOSE: Atherosclerosis is a complex disorder with hereditary and environmental causes. Carotid artery intima-media wall thickness (IMT) is a useful measure of atherosclerosis. The objective of this study was to determine the association between carotid IMT and functional promoter variants of stromelysin-1 (MMP3: -1612 5A>6A), interleukin-6 (IL6: -174G>C), and hepatic lipase (HL: -480C>T) genes....
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