Article
Interleukin-6 promoter polymorphism modulates the effects of heavy alcohol consumption on early carotid artery atherosclerosis: the Carotid Atherosclerosis Progression Study (CAPS).
Stroke - 1 Feb 2003
Jerrard-Dunne Paula, Sitzer Matthias, Risley Paul, Steckel Donata A, Buehler Alexandra, von Kegler Stefan, Markus Hugh S
Abstract excerpt
BACKGROUND AND PURPOSE: A J-shaped relationship has been demonstrated between alcohol and both clinical cardiovascular events and carotid atherosclerosis. A similar J-shaped relationship has been found between alcohol intake and inflammatory markers. If inflammation were on the intermediate causal pathway between alcohol intake and atherosclerosis, then genetic determinants of enhanced inflammation would be...
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