Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transchromosomal mouse embryonic stem cell lines and chimeric mice that contain freely segregating segments of human chromosome 21.

Human molecular genetics - 1 May 1999

Hernandez D, Mee P J, Martin J E, Tybulewicz V L, Fisher E M

Abstract excerpt

At least 8% of all human conceptions have major chromosome abnormalities and the frequency of chromosomal syndromes in newborns is >0.5%. Despite these disorders making a large contribution to human morbidity and mortality, we have little understanding of their aetiology and little molecular data...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aneuploidy
Share to Chimera
Share to Chromosome Segregation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 21

Share to Embryo, Mammalian

Share to Gene Transfer Techniques

Share to Genetic Techniques

Share to Kanamycin Kinase

Source

Identifiers

PMID: 10196383
DOI: 10.1093/hmg/8.5.923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10196383-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transchromosomal mouse embryonic stem cell lines and chimeric mice that contain freely segregating segments of human chromosome 21.PMID 10196383Read ↗

Massively Parallel Sequencing Reveals the Complex Structure of an Irradiated Human Chromosome on a Mouse Background in the Tc1 Model of Down SyndromeSemantic proximity Read ↗

A non-mosaic transchromosomic mouse model of Down syndrome carrying the long arm of human chromosome 21Semantic proximity Read ↗

A non-mosaic humanized mouse model of Down syndrome, trisomy of a nearly complete long arm of human chromosome 21 in mouse chromosome backgroundSemantic proximity Read ↗

Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down's syndrome.Semantic proximity Read ↗

An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.Semantic proximity Read ↗

Mouse-based genetic modeling and analysis of Down syndromeSemantic proximity Read ↗

Down syndrome: searching for the genetic culpritsSemantic proximity Read ↗

A new mouse model for Down syndrome.Semantic proximity Read ↗

The first transchromosomic rat model with human chromosome 21 shows robust Down syndrome featuresSemantic proximity Read ↗

Trisomy 21 and Down syndrome: a short review.Semantic proximity Read ↗

Down syndrome--recent progress and future prospectsSemantic proximity Read ↗

Down syndrome mouse models are looking up.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.