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Article

Developmental defects in trisomy 21 and mouse models.

TheScientificWorldJournal - 19 Sept 2006

Delabar Jean Maurice, Aflalo-Rattenbac Revital, Créau Nicole

Abstract excerpt

Aneuploidies have diverse phenotypic consequences, ranging from mental retardation and developmental abnormalities to susceptibility to common phenotypes and various neoplasms. This review focuses on the developmental defects of murine models of a prototype human aneuploidy: trisomy 21 (Down syndrome, DS, T21). Murine models are clearly the best tool for dissecting the phenotypic consequences of imbalances that...

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Identifiers

PMID: 17205199
DOI: 10.1100/tsw.2006.322
PMCID: PMC5917200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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