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Article

A non-mosaic transchromosomic mouse model of Down syndrome carrying the long arm of human chromosome 21

29 Jun 2020

Abstract excerpt

Animal models of Down syndrome (DS), trisomic for human chromosome 21 (HSA21) genes or orthologs, provide insights into better understanding and treatment options. The only existing transchromosomic (Tc) mouse DS model, Tc1, carries a HSA21 with over 50 protein coding genes (PCGs) disrupted. Tc1 is mosaic, compromising interpretation of results. Here, we "clone" the 34 MB long arm of HSA21 (HSA21q) as a mouse...

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PMID: 32597754
DOI: 10.7554/elife.56223

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