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Mouse-based genetic modeling and analysis of Down syndrome

3 Oct 2016

Abstract excerpt

INTRODUCTION: Down syndrome (DS), caused by human trisomy 21 (Ts21), can be considered as a prototypical model for understanding the effects of chromosomal aneuploidies in other diseases. Human chromosome 21 (Hsa21) is syntenically conserved with three regions in the mouse genome. SOURCES OF DATA: A review of recent advances in genetic modeling and analysis of DS. Using Cre/loxP-mediated chromosome engineering, a...

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PMID: 27789459
DOI: 10.1093/bmb/ldw040

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