Article

The first transchromosomic rat model with human chromosome 21 shows robust Down syndrome features

2021-10-04

Abstract excerpt

Progress in earlier detection and symptom management has increased life expectancy and quality of life in people with Down syndrome (DS). However, no drug has been approved to help individuals with DS live independently and fully. Although rat models could support more robust physiological, behavioral, and toxicology analysis than mouse models during preclinical validation, no DS rat model is available due to tech...

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Literature Corpus work: fceccd70-12c5-5277-af16-39afcba06263
DOI: 10.1101/2021.10.03.462958

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