Article
Internalization and desensitization of the oxytocin receptor is inhibited by Dynamin and clathrin mutants in human embryonic kidney 293 cells.
Molecular endocrinology (Baltimore, Md.) - 1 Feb 2006
Smith M P, Ayad V J, Mundell S J, McArdle C A, Kelly E, López Bernal A
Abstract excerpt
Oxytocin (OT) has long been used as an uterotonic during labor management in women, and yet responses to OT infusion remain variable and unpredictable among patients. The investigation of oxytocin receptor (OTR) regulation will benefit labor management, because the clinical practice of continuous iv infusion of OT is not optimal. As with other G protein-coupled receptors, it is likely that the OTR internalizes...
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