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Article

Amino acids in the COOH-terminal region of the oxytocin receptor third intracellular domain are important for receptor function.

American journal of physiology. Endocrinology and metabolism - 1 Apr 2007

Zhong Miao, Parish Bridgette, Murtazina Dilyara A, Ku Chun-Ying, Sanborn Barbara M

Abstract excerpt

Previously, residue K6.30 in the COOH-terminal region of the third intracellular domain (3iC) of the oxytocin (OT) receptor (OTR) was identified as important for receptor function leading to phospholipase C activation in both OTR and the vasopressin V(2) receptor (V(2)R) chimera V(2)ROTR3iC. Substitution of either A6.28K or V6.30K in wild-type V(2)R did not recapitulate the increase in phosphatidylinositide (PI)...

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Identifiers

PMID: 17148753
DOI: 10.1152/ajpendo.00531.2005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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