Article
Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines.
Blood - 15 Jan 2006
Zhou Gang, Drake Charles G, Levitsky Hyam I
Abstract excerpt
The fate of tumor-specific CD4(+) T cells is central to the outcome of the host immune response to cancer. We show that tumor antigen recognition by a subset of CD4(+) T cells led to their differentiation into cells capable of suppressing naive and Th1 effector cells. Such tumor-induced regulatory T cells (TMTregs) arose both from precommitted "natural" regulatory T cells and CD4(+)CD25(-)GITR(low) precursors....
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