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Article

Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A.

The Journal of biological chemistry - 18 Nov 2005

Han Gil-Soo, Sreenivas Avula, Choi Mal-Gi, Chang Yu-Fang, Martin Shelley S, Baldwin Enoch P, Carman George M

Abstract excerpt

CTP synthetase (EC 6.3.4.2, UTP:ammonia ligase (ADP-forming)) is an essential enzyme in all organisms; it generates the CTP required for the synthesis of nucleic acids and membrane phospholipids. In this work we showed that the human CTP synthetase genes, CTPS1 and CTPS2, were functional in Saccharomyces cerevisiae and complemented the lethal phenotype of the ura7Delta ura8Delta mutant lacking CTP synthetase...

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Identifiers

PMID: 16179339
DOI: 10.1074/jbc.M509622200
PMCID: PMC1400552

Genes

CTPS1
CTPS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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