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Molecular Cloning, Expression, and Characterization of Human Bifunctional 3′-Phosphoadenosine 5′-Phosphosulfate Synthase and Its Functional Domains

1 Jul 1998

Abstract excerpt

The universal sulfonate donor, 3'-phosphoadenosine 5'-phosphosulfate (PAPS), is synthesized by the concerted action of ATP sulfurylase and adenosine 5'-phosphosulfate (APS) kinase, which in animals are fused into a bifunctional protein. The cDNA for human PAPS synthase (hPAPSS) along with polymerase chain reaction products corresponding to several NH2- and COOH-terminal fragments were cloned and expressed in...

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PMID: 9668121
DOI: 10.1074/jbc.273.30.19311

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