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Group A Streptococcal asparagine metabolism regulates bacterial virulence

14 Apr 2025

Abstract excerpt

Group A Streptococcus (GAS) causes various human diseases linked to virulome expression predominantly regulated by the two-component system (TCS), CovR/S. Here, we demonstrate that asparagine (Asn) presence in a minimal chemically defined medium increases virulence gene expression in a CovR-dependent fashion. It also decreases the transcription of asparagine synthetase (AsnA), the ABC transporter responsible for...

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PMID: 40229432
DOI: 10.1038/s44319-025-00447-z

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