Article
Electrophysiological and behavioral phenotype of insulin receptor defective mice.
Physiology & behavior - 15 Oct 2005
Das P, Parsons A D, Scarborough J, Hoffman J, Wilson J, Thompson R N, Overton J M, Fadool D A
Abstract excerpt
The olfactory bulb expresses one of the highest levels of insulin found in the brain. A high level of expression of the concomitant insulin receptor (IR) kinase is also retained in this brain region, even in the adult. We have previously demonstrated in a heterologous system that insulin modulates the voltage-dependent potassium channel, Kv1.3, through tyrosine phosphorylation of three key residues in the amino...
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