Article
Evaluating whole genome amplification via multiply-primed rolling circle amplification for SNP genotyping of samples with low DNA yield.
Twin research and human genetics : the official journal of the International Society for Twin Studies - 1 Aug 2005
Silander Kaisa, Komulainen Kati, Ellonen Pekka, Jussila Minttu, Alanne Mervi, Levander Minna, Tainola Päivi, Kuulasmaa Kari, Salomaa Veikko, Perola Markus, Peltonen Leena, Saarela Janna
Abstract excerpt
The amount of available DNA is often a limiting factor in pursuing genetic analyses of large-scale population cohorts. An association between higher DNA yield from blood and several phenotypes associated with inflammatory states has recently been demonstrated, suggesting that exclusion of samples with very low DNA yield may lead to biased results in statistical analyses. Whole genome amplification (WGA) could...
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