Article
High quality genome-wide genotyping from archived dried blood spots without DNA amplification.
PloS one - 1 Jan 2013
St Julien Krystal R, Jelliffe-Pawlowski Laura L, Shaw Gary M, Stevenson David K, O'Brodovich Hugh M, Krasnow Mark A
Abstract excerpt
Spots of blood are routinely collected from newborn babies onto filter paper called Guthrie cards and used to screen for metabolic and genetic disorders. The archived dried blood spots are an important and precious resource for genomic research. Whole genome amplification of dried blood spot DNA has been used to provide DNA for genome-wide SNP genotyping. Here we describe a 96 well format procedure to extract DNA...
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