Article
Rates of transition and transversion in coding sequences since the human-rodent divergence.
Genomics - 1 Apr 1994
Collins D W, Jukes T H
Abstract excerpt
Protein-coding sequences of 337 human genes were compared with those of homologous genes from rodent (mouse or rat). A composite alignment containing 477,189 nucleotide positions was constructed, and 21,570 amino acid replacements were inferred. The rates of transitional and transversional silent substitutions in fourfold degenerate sites are estimated as 1.71 x 10(-9) and 1.22 x 10(-9) site -1 year -1,...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Evolution
- Codon
- Genetic Variation
- Hominidae
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Odds Ratio