Article
Natural selection shaped regional mtDNA variation in humans.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2003
Mishmar Dan, Ruiz-Pesini Eduardo, Golik Pawel, Macaulay Vincent, Clark Andrew G, Hosseini Seyed, Brandon Martin, Easley Kirk, Chen Estella, Brown Michael D, Sukernik Rem I, Olckers Antonel, Wallace Douglas C
Abstract excerpt
Human mtDNA shows striking regional variation, traditionally attributed to genetic drift. However, it is not easy to account for the fact that only two mtDNA lineages (M and N) left Africa to colonize Eurasia and that lineages A, C, D, and G show a 5-fold enrichment from central Asia to Siberia. As an alternative to drift, natural selection might have enriched for certain mtDNA lineages as people migrated north...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.