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Article

Evidence for adaptive selection acting on the tRNA and rRNA genes of human mitochondrial DNA.

Human mutation - 1 Nov 2006

Ruiz-Pesini Eduardo, Wallace Douglas C

Abstract excerpt

In order to identify putative adaptive human mitochondrial DNA (mtDNA), transfer RNA (tRNA), and ribosomal RNA (rRNA) variants, we assembled a sequential mutational tree from 2,460 human mtDNA coding sequences, thus providing the relative age of all mtDNA sequence variants. Deleterious mutations affect evolutionarily conserved nucleotides and have been eliminated from the older internal branches of the tree by...

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Share to DNA, Mitochondrial
Share to Genes, rRNA
Share to Nucleic Acid Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to RNA, Ribosomal

Share to RNA, Ribosomal, 16S

Share to RNA, Transfer

Share to Selection, Genetic

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Identifiers

PMID: 16947981
DOI: 10.1002/humu.20378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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