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Article

Modifier loci condition autoimmunity provoked by Aire deficiency.

The Journal of experimental medicine - 19 Sept 2005

Jiang Wenyu, Anderson Mark S, Bronson Roderick, Mathis Diane, Benoist Christophe

Abstract excerpt

Loss of function mutations in the autoimmune regulator (Aire) gene in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients and mutant mice lead to autoimmune manifestations that segregate as a monogenic trait, but with wide variation in the spectrum of organs targeted. To investigate the cause of this variability, the Aire knockout mutation was backcrossed to mice of diverse genetic...

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Identifiers

PMID: 16172259
DOI: 10.1084/jem.20050693
PMCID: PMC2212943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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