Differential expression of CD45 isoforms is controlled by the combined activity of basal and inducible splicing-regulatory elements in each of the variable exons.

Abstract excerpt

The human CD45 gene encodes five isoforms of a transmembrane tyrosine phosphatase that differ in their extracellular domains as a result of alternative splicing of exons 4-6. Expression of the CD45 isoforms is tightly regulated in peripheral T cells such that resting cells predominantly express the larger CD45 isoforms, encoded by mRNAs containing two or three variable exons. In contrast, activated T cells...

Topics

• Alternative Splicing
• Amino Acid Motifs
• Base Sequence
• Cross-Linking Reagents
• Enhancer Elements, Genetic
• Exons
• Gene Expression Regulation
• Gene Silencing
• Heterogeneous-Nuclear Ribonucleoprotein L
• Humans