Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A CD45 polymorphism associated with multiple sclerosis disrupts an exonic splicing silencer.

The Journal of biological chemistry - 29 Jun 2001

Lynch K W, Weiss A

Abstract excerpt

Previous studies have identified a single nucleotide polymorphism that significantly increases the splicing of variable exon 4 in transcripts of the human protein-tyrosine phosphatase CD45. Strikingly, the presence of this polymorphism correlates with susceptibility to the autoimmune disease multiple sclerosis. In this study we investigated the mechanism by which the polymorphism enhances splicing of CD45 exon 4....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Leukocyte Common Antigens
Share to Models, Biological

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Multiple Sclerosis

Share to Regulatory Sequences, Nucleic Acid

Share to RNA-Binding Proteins

Share to RNA Splice Sites

Source

Identifiers

PMID: 11306584
DOI: 10.1074/jbc.M102175200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A CD45 polymorphism associated with multiple sclerosis disrupts an exonic splicing silencer.PMID 11306584Read ↗

A disease-associated polymorphism alters splicing of the human CD45 phosphatase gene by disrupting combinatorial repression by heterogeneous nuclear ribonucleoproteins (hnRNPs).Semantic proximity Read ↗

A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4.Semantic proximity Read ↗

Differential expression of CD45 isoforms is controlled by the combined activity of basal and inducible splicing-regulatory elements in each of the variable exons.Semantic proximity Read ↗

A functional variant that affects exon-skipping and protein expression of SP140 as genetic mechanism predisposing to multiple sclerosis.Semantic proximity Read ↗

Alu insertion variants alter mRNA splicingSemantic proximity Read ↗

Altered CD45 expression and disease.Semantic proximity Read ↗

Identification and characterization of a human CD4 silencer.Semantic proximity Read ↗

Unusual case presentations associated with the CD45 C77G polymorphism.Semantic proximity Read ↗

Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing.Semantic proximity Read ↗

The ITPA c.94C>A and g.IVS2+21A>C sequence variants contribute to missplicing of the ITPA gene.Semantic proximity Read ↗

A point mutation in CD45 may be associated with an increased risk of HIV-1 infection.Semantic proximity Read ↗

HnRNP L and L-like cooperate in multiple-exon regulation of CD45 alternative splicing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.