The alternative splicing of the CD45 tyrosine phosphatase is controlled by negative regulatory trans-acting splicing factors.

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Article

The alternative splicing of the CD45 tyrosine phosphatase is controlled by negative regulatory trans-acting splicing factors.

The Journal of biological chemistry - 5 Apr 1992

Rothstein D M, Saito H, Streuli M, Schlossman S F, Morimoto C

Abstract excerpt

CD45, a receptor-type protein tyrosine phosphatase involved in lymphocyte activation, consists of five isoforms generated by alternative mRNA splicing. The pattern of CD45 splicing depends upon cell type, state of activation, and thymic development. We previously showed that mouse B and thymocyte cell lines transfected with a human CD45 minigene construct appropriately splice the alternative exons, demonstrating...

Topics

Animals
Antigens, CD
B-Lymphocytes
Base Sequence
Blotting, Southern
DNA
Histocompatibility Antigens
Humans
Leukocyte Common Antigens
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Plasmids

Polymerase Chain Reaction

Protein Tyrosine Phosphatases

RNA Splicing

RNA, Messenger

T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 1532394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1532394-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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