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α6-Integrin alternative splicing: distinct cytoplasmic variants in stem cell fate specification and niche interaction

2 May 2018

Abstract excerpt

α6-Integrin subunit (also known as CD49f) is a stemness signature that has been found on the plasma membrane of more than 30 stem cell populations. A growing body of studies have focused on the critical role of α6-containing integrins (α6β1 and α6β4) in the regulation of stem cell properties, lineage-specific differentiation, and niche interaction. α6-Integrin subunit can be alternatively spliced at the...

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PMID: 29720266
DOI: 10.1186/s13287-018-0868-3

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