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Article

HnRNP L and L-like cooperate in multiple-exon regulation of CD45 alternative splicing.

Nucleic acids research - 1 Jul 2012

Preussner Marco, Schreiner Silke, Hung Lee-Hsueh, Porstner Martina, Jäck Hans-Martin, Benes Vladimir, Rätsch Gunnar, Bindereif Albrecht

Abstract excerpt

CD45 encodes a trans-membrane protein-tyrosine phosphatase expressed in diverse cells of the immune system. By combinatorial use of three variable exons 4-6, isoforms are generated that differ in their extracellular domain, thereby modulating phosphatase activity and immune response. Alternative splicing of these CD45 exons involves two heterogeneous ribonucleoproteins, hnRNP L and its cell-type specific paralog...

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Identifiers

PMID: 22402488
DOI: 10.1093/nar/gks221
PMCID: PMC3384337

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Source receipt: pubmed, retrieved 7 Sept 2026.

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