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Article

Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay.

Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2012

Alexandrov Andrei, Colognori David, Shu Mei-Di, Steitz Joan A

Abstract excerpt

The multiprotein exon junction complex (EJC) that is deposited upstream of spliced junctions orchestrates downstream events in the life of a metazoan mRNA, including its surveillance via the nonsense-mediated decay (NMD) pathway. However, the mechanism by which the spliceosome mediates EJC formation is not well understood. We show that human eIF4G-like spliceosomal protein (h)CWC22 directly interacts with the...

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Identifiers

PMID: 23236153
DOI: 10.1073/pnas.1219725110
PMCID: PMC3535618

Genes

CWC22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay.PMID 23236153Read ↗

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