Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The C-type lectin fold as an evolutionary solution for massive sequence variation.

Nature structural & molecular biology - 1 Oct 2005

McMahon Stephen A, Miller Jason L, Lawton Jeffrey A, Kerkow Donald E, Hodes Asher, Marti-Renom Marc A, Doulatov Sergei, Narayanan Eswar, Sali Andrej, Miller Jeff F, Ghosh Partho

Abstract excerpt

Only few instances are known of protein folds that tolerate massive sequence variation for the sake of binding diversity. The most extensively characterized is the immunoglobulin fold. We now add to this the C-type lectin (CLec) fold, as found in the major tropism determinant (Mtd), a retroelement-encoded receptor-binding protein of Bordetella bacteriophage. Variation in Mtd, with its approximately 10(13)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Outer Membrane Proteins
Share to Bacteriophages

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Viral

Share to Lectins, C-Type

Share to Protein Conformation

Share to Protein Folding

Share to Viral Proteins

Share to Virulence Factors, Bordetella

Source

Identifiers

PMID: 16170324
DOI: 10.1038/nsmb992

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The C-type lectin fold as an evolutionary solution for massive sequence variation.PMID 16170324Read ↗

Conservation of the C-type lectin fold for massive sequence variation in a <i>Treponema</i> diversity-generating retroelementSemantic proximity Read ↗

Selective ligand recognition by a diversity-generating retroelement variable protein.Semantic proximity Read ↗

Diversity-generating Retroelements in Phage and Bacterial Genomes.Semantic proximity Read ↗

Comparative analysis of structural properties of the C‐type‐lectin‐like domain (CTLD)Semantic proximity Read ↗

Dissection of the IgNAR V domain: molecular scanning and orthologue database mining define novel IgNAR hallmarks and affinity maturation mechanisms.Semantic proximity Read ↗

Rapid Evolution of Glycan Recognition Receptors Reveals an Axis of Host-Microbe Conflicts at Carbohydrate-Protein InterfacesSemantic proximity Read ↗

Tracing ancestral specificity of lectins: ancestral sequence reconstruction method as a new approach in protein engineering.Semantic proximity Read ↗

Mapping Structural Constraints and Adaptive Potential in a Capsule-Degrading Phage Tailspike ProteinSemantic proximity Read ↗

Structural Determinants of Species-Specific Mannose-Binding Lectin Recognition of Brucella melitensis M-Antigen: A Comparative Genomics and Molecular Dynamics StudySemantic proximity Read ↗

Accelerated Evolution by Diversity-Generating Retroelements.Semantic proximity Read ↗

Mapping the functional landscape of the receptor binding domain of T7 bacteriophage by deep mutational scanning.Semantic proximity Read ↗

Recombination-driven generation of the largest pathogen repository of antigen variants in the protozoan Trypanosoma cruziSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.