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Structural Determinants of Species-Specific Mannose-Binding Lectin Recognition of Brucella melitensis M-Antigen: A Comparative Genomics and Molecular Dynamics Study

2025-10-31

Abstract excerpt

<title>Abstract</title> <p> Mannose-binding lectin (MBL) is a pivotal innate immune protein that recognizes pathogen surface glycans, including <italic>Brucella melitensis</italic> ’s immunosuppressive M-antigen. This study deciphers how interspecies MBL variation influences M-antigen binding and informs model selection for anti-brucellosis strategies. Using comparative genomics, phylogenetics, and computation...

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Literature Corpus work: dd73c075-ed12-51ab-b938-fe45a3592b5f
DOI: 10.21203/rs.3.rs-7619360/v1

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