Conservation of the C-type lectin fold for massive sequence variation in a <i>Treponema</i> diversity-generating retroelement

Abstract excerpt

Anticipatory ligand binding through massive protein sequence variation is rare in biological systems, having been observed only in the vertebrate adaptive immune response and in a phage diversity-generating retroelement (DGR). Earlier work has demonstrated that the prototypical DGR variable protein, major tropism determinant (Mtd), meets the demands of anticipatory ligand binding by novel means through the C-type...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antimicrobial Peptides and Activities
• Share to Syphilis Diagnosis and Treatment
• Share to T-cell and B-cell Immunology