Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An evaluation of the ability of pifithrin-α and -β to inhibit p53 function in two wild-type p53 human tumor cell lines

1 Sept 2005

Abstract excerpt

The small-molecule compound pifithrin-alpha (PFT-alpha) has been reported to inhibit p53 function and protect against a variety of genotoxic agents. We show here that PFT-alpha is unstable in tissue culture medium and is rapidly converted to its condensation product PFT-beta. Both compounds showed limited solubility with PFT-alpha precipitating out of tissue culture medium at concentrations >30 micromol/L....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cell death mechanisms and regulation
Share to Retinoids in leukemia and cellular processes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16170029
DOI: 10.1158/1535-7163.mct-04-0341

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An evaluation of the ability of pifithrin-α and -β to inhibit p53 function in two wild-type p53 human tumor cell linesPMID 16170029Read ↗

An evaluation of small-molecule p53 activators as chemoprotectants ameliorating adverse effects of anticancer drugs in normal cellsSemantic proximity Read ↗

High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated Tp53-responsive luciferase reporterSemantic proximity Read ↗

The Mutant p53-Conformation Modifying Drug, CP-31398, Can Induce ApoptosisSemantic proximity Read ↗

Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines.Semantic proximity Read ↗

Acute cytotoxicity of MIRA-1/NSC19630, a mutant p53-reactivating small molecule, against human normal and cancer cells via a caspase-9-dependent apoptosis.Semantic proximity Read ↗

Aciculatin Induces p53-Dependent Apoptosis via MDM2 Depletion in Human Cancer Cells In Vitro and In VivoSemantic proximity Read ↗

Suppression of Apoptosis by PIF1 Helicase in Human Tumor CellsSemantic proximity Read ↗

Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors.Semantic proximity Read ↗

Cellular Response to Chemoradiotherapy, Radiotherapy and Chemotherapy in Two Colorectal Cancer Cell LinesSemantic proximity Read ↗

Differential p53-dependent mechanism of radiosensitization in vitro and in vivo by the protein kinase C-specific inhibitor PKC412.Semantic proximity Read ↗

The investigational new drug XK469 induces G(2)-M cell cycle arrest by p53-dependent and -independent pathways.Semantic proximity Read ↗

Human T-cell leukemia virus I tax protein sensitizes p53-mutant cells to DNA damage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.