Article
Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors.
Cancer research - 1 Mar 2005
Carvajal Daisy, Tovar Christian, Yang Hong, Vu Binh T, Heimbrook David C, Vassilev Lyubomir T
Abstract excerpt
Recent studies have shown that activation of cell cycle checkpoints can protect normal proliferating cells from mitotic inhibitors by preventing their entry into mitosis. These studies have used genotoxic agents that act, at least in part, by activation of the p53 pathway. However, genotoxic drugs are known also to have p53-independent activities and could affect the sensitivity of tumor cells to antimitotic...
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