Article
Acute cytotoxicity of MIRA-1/NSC19630, a mutant p53-reactivating small molecule, against human normal and cancer cells via a caspase-9-dependent apoptosis.
Cancer letters - 10 Apr 2015
Bou-Hanna Chantal, Jarry Anne, Lode Laurence, Schmitz Ingo, Schulze-Osthoff Klaus, Kury Sébastien, Bezieau Stéphane, Mosnier Jean-François, Laboisse Christian L
Abstract excerpt
Although numerous studies have focused on the mechanisms of action of the candidate chemotherapeutic drug MIRA-1/NSC19630, initially described as a mutant p53-reactivating small molecule, the issue of its toxicological evaluation remains open. Here, we devised a strategy to examine the effects of MIRA-1 on a variety of human normal cells and cancer cell lines. First, we demonstrated a massive and rapid (within 2...
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