Article
Yeast caspase 1 links messenger RNA stability to apoptosis in yeast.
EMBO reports - 1 Nov 2005
Mazzoni Cristina, Herker Eva, Palermo Vanessa, Jungwirth Helmut, Eisenberg Tobias, Madeo Frank, Falcone Claudio
Abstract excerpt
During the past years, yeasts have been successfully established as models to study the mechanisms of apoptotic regulation. We recently showed that mutations in the LSM4 gene, which is involved in messenger RNA decapping, lead to increased mRNA stability and apoptosis in yeast. Here, we show that mitochondrial function and YCA1, which encodes a budding yeast metacaspase, are necessary for apoptosis triggered by...
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