Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Kluyveromyces lactis mutant in the essential gene KlLSM4 shows phenotypic markers of apoptosis.

FEMS yeast research - 1 Oct 2003

Mazzoni Cristina, Mancini Patrizia, Madeo Frank, Palermo Vanessa, Falcone Claudio

Abstract excerpt

We report the study of Kluyveromyces lactis cells expressing a truncated form of KlLSM4, a gene ortholog to LSM4 of Saccharomyces cerevisiae which encodes an essential protein involved in both pre-mRNA splicing and mRNA decapping. We had previously demonstrated that the first 72 amino acids of the K. lactis Lsm4p (KlLsm4Deltap) can restore cell growth in both K. lactis and S. cerevisiae cells not expressing the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Genes, Essential
Share to Genes, Fungal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Markers

Share to Kluyveromyces

Share to Phenotype

Share to Reactive Oxygen Species

Share to RNA, Messenger

Source

Identifiers

PMID: 14554194
DOI: 10.1016/S1567-1356(03)00151-X

Genes

LSM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Kluyveromyces lactis mutant in the essential gene KlLSM4 shows phenotypic markers of apoptosis.PMID 14554194Read ↗

A truncated form of KlLsm4p and the absence of factors involved in mRNA decapping trigger apoptosis in yeast.Semantic proximity Read ↗

Yeast Lsm Pro-Apoptotic Mutants Show Defects in Autophagy.Semantic proximity Read ↗

PGK1, the gene encoding the glycolitic enzyme phosphoglycerate kinase, acts as a multicopy suppressor of apoptotic phenotypes in S. cerevisiae.Semantic proximity Read ↗

Yeast caspase 1 links messenger RNA stability to apoptosis in yeast.Semantic proximity Read ↗

HIR1, the co-repressor of histone gene transcription of Saccharomyces cerevisiae, acts as a multicopy suppressor of the apoptotic phenotypes of the LSM4 mRNA degradation mutant.Semantic proximity Read ↗

Yeast lsm pro-apoptotic mutants show defects in S-phase entry and progression.Semantic proximity Read ↗

Increased levels of RNA oxidation enhance the reversion frequency in aging pro-apoptotic yeast mutants.Semantic proximity Read ↗

Analysis of Lsm1p and Lsm8p domains in the cellular localization of Lsm complexes in budding yeast.Semantic proximity Read ↗

Cloning and characterization of KlCOX18, a gene required for activity of cytochrome oxidase in Kluyveromyces lactis.Semantic proximity Read ↗

Disruption of Rpn4-Induced Proteasome Expression in Saccharomyces cerevisiae Reduces Cell Viability Under Stressed ConditionsSemantic proximity Read ↗

Lsm proteins are required for normal processing of pre-tRNAs and their efficient association with La-homologous protein Lhp1p.Semantic proximity Read ↗

A non-death role of the yeast metacaspase: Yca1p alters cell cycle dynamics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.