Article
Association of MMP-9 gene polymorphisms with atrial fibrillation in hypertensive heart disease patients.
Clinica chimica acta; international journal of clinical chemistry - 1 Oct 2009
Gai Xiaobo, Lan Xiaopeng, Luo Zhurong, Wang Feifei, Liang Yonggang, Zhang Hueimin, Zhang Wenli, Hou Jianping, Huang Mingfang
Abstract excerpt
BACKGROUND: MMP-9 plays an important role in the pathogenesis of arrhythmogenic atrial remodeling, and may contribute to the development and persistence of atrial fibrillation (AF). Functional polymorphisms in the MMP-9 gene which lead to altered MMP-9 production and/or activity may modulate an individual's susceptibility to AF. METHODS: A total of 881 hypertensive heart disease patients of Chinese Han population...
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