A mouse model for hemoglobin SC disease recapitulates characteristic human pathologies.

doi:10.1182/bloodadvances.2025016793

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A mouse model for hemoglobin SC disease recapitulates characteristic human pathologies.

Blood advances - 9 Dec 2025

Zhai Jinbin, Papizan James B, Yao Yu, Arnold Elizabeth D, Yu Jing, Tran Tam, Geiger Natalie, Gollamudi Jahnavi, Little Danielle R, Jadeja Ravirajsinh N, John Jaison, Khalighifar Ali, Mayberry Kalin, McEvoy Justina, Rooney Randi, Venkataraman Krishnan, Vu Hieu S, Zhang Jingjing, Dyer Michael, Gallagher Patrick G, Hyacinth Hyacinth I, Janke Laura J, Martin Pamela M, Ni Min, Xu Jian, Yen Jonathan S, Zheng Yan, Weiss Mitchell J, Pruett-Miller Shondra M

Abstract excerpt

ABSTRACT: Sickle cell disease (SCD) is a common, life-threatening group of disorders caused by missense mutations in the β-globin gene (HBB). Mouse models have helped to elucidate the most common form of SCD (hemoglobin SS [HbSS]; homozygous p.Glu6Val) and develop new therapies. In contrast, a lack of animal models has restricted research on the second most common form of SCD (hemoglobin SC [HbSC];...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to alpha-Globins

Share to Anemia, Sickle Cell

Share to beta-Globins

Share to Disease Models, Animal

Share to HBB gene

Share to SCD gene

Share to Mice

Source

Open in PubMed Open full text

Identifiers

PMID: 40864227
DOI: 10.1182/bloodadvances.2025016793
PMCID: PMC12745012

Genes

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mouse model for hemoglobin SC disease recapitulates characteristic human pathologies.PMID 40864227Read ↗

A novel mouse model of hemoglobin SC disease reveals mechanisms underlying beneficial effects of hydroxyureaSemantic proximity Read ↗

Phenotypic Characterization the Townes Sickle MiceSemantic proximity Read ↗

Challenges and opportunities for conceiving genetically diverse sickle cell mice.Semantic proximity Read ↗

Base editing HbS to HbG-Makassar improves hemoglobin function supporting its use in sickle cell disease.Semantic proximity Read ↗

Mouse models of sickle cell disease: Imperfect and yet very informativeSemantic proximity Read ↗

In vivo HSC prime editing rescues Sickle Cell Disease in a mouse modelSemantic proximity Read ↗

Sickle Cell Disease: From Genetics to Curative ApproachesSemantic proximity Read ↗

The paradox of HbSC disease-Not so benign after all.Semantic proximity Read ↗

Installation of HbG-Makassar by base editing restores hemoglobin function: a transformative therapy for sickle cell diseaseSemantic proximity Read ↗

Revolutionising healing: Gene Editing's breakthrough against sickle cell diseaseSemantic proximity Read ↗

Limitations of mouse models for sickle cell disease conferred by their human globin transgene configurationsSemantic proximity Read ↗

End Organ Affection in Sickle Cell DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.