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Article

Cardiorespiratory pathogenesis of sickle cell disease in a mouse model.

Scientific reports - 17 Aug 2017

Ren Jun, Ding Xiuqing, Trudel Marie, Greer John J, MacLean Joanna E

Abstract excerpt

The nature and development of cardiorespiratory impairments associated with sickle cell disease are poorly understood. Given that the mechanisms of these impairments cannot be addressed adequately in clinical studies, we characterized cardiorespiratory pathophysiology from birth to maturity in the sickle cell disease SAD mouse model. We identified two critical phases of respiratory dysfunction in SAD mice; the...

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Identifiers

PMID: 28819305
DOI: 10.1038/s41598-017-08860-8
PMCID: PMC5561125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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